Igf1r CLIA Kit for Mouse(Mus musculus) | EIAab.comIgf1r CLIA Kit for Mouse(Mus musculus)

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Igf1r (Gene name),

Insulin-like growth factor 1 receptor (Protein name ), IGF1R_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Igf1r;

Protein name:

Insulin-like growth factor 1 receptor;

Alternative:

Insulin-like growth factor I receptor(IGF-I receptor);

CD:

CD221;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1.

Function:

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1373

Sequence:

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1350:

1373:

PYAHMNGGRA | NERALPLPQS | STC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.275742

KEGG:

mmu:16001

SMR:

Q60751

Pfam:

PF00041

String:

Q60751

Uniprot:

Q60751

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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

Cat.:

E1200h

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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

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E1200p

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96T

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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

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E1200b

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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

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E1200r

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ELISA Kit for Mouse Insulin-like growth factor 1 receptor

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E1200m

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CLIA Kit for Mouse Insulin-like growth factor 1 receptor

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CLIA Kit for Mouse Insulin-like growth factor 1 receptor

Cat.:

U1200p

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96T

CLIA Kit for Mouse Insulin-like growth factor 1 receptor

Cat.:

U1200m

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96T

CLIA Kit for Mouse Insulin-like growth factor 1 receptor

Cat.:

U1200h

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96T

CLIA Kit for Mouse Insulin-like growth factor 1 receptor

Cat.:

U1200r

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96T

Polyclonal Antibody for Mouse Insulin-like growth factor 1 receptor

Cat.:

P1200Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Insulin-like growth factor 1 receptor

Cat.:

P1200Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Insulin-like growth factor 1 receptor

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P1200Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Insulin-like growth factor 1 receptor

Monoclonal Antibody for Mouse Insulin-like growth factor 1 receptor

Protein for Mouse Insulin-like growth factor 1 receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of cDNA for the mouse insulin-like growth factor I receptor."
Navarro M. , Garandel V. , Barenton B. , Bernardi H.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development."
Wada J. , Liu Z.Z. , Alvares K. , Kumar A. , Wallner E.I. , Makino H. , Kanwar Y.S.
Proc. Natl. Acad. Sci. U.S.A.90:10360-10364(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-329
strain: CD-1.
tissue: Kidney.
3.

"The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family."
Wilks A.F. , Kurban R.R. , Hovens C.M. , Ralph S.J.
Gene85:67-74(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1134-1203
4.

"Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)."
Liu J.P. , Baker J. , Perkins A.S. , Robertson E.J. , Efstratiadis A.
Cell75:59-72(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
5.

"Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts."
Buckley D.A. , Cheng A. , Kiely P.A. , Tremblay M.L. , O'Connor R.
Mol. Cell. Biol.22:1998-2010(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
6.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-748 AND ASN-901
tissue: Myoblast.
7.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-639; ASN-641; ASN-757 AND ASN-765
8.

"Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth."
Kelly G.M. , Buckley D.A. , Kiely P.A. , Adams D.R. , O'Connor R.
J. Biol. Chem.287:28180-28194(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1280 AND SER-1284

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